The article provides information obtained from the study of osteological subfossil material from Ust-Keul I site in Northern Angara region. About five thousand pieces belong to vertebrates especially mammals. The remains of domestic and commercial animals were determined in the region of Angara river during various segments of the Holocene. These species are the objects of human activity during the whole process of cultural developing of the region. The characteristic of stratification levels is given as well as different cultural periods by the determination of faunal assemblage. Dominating species are deers: moose, roe deer, red deer. In the Early Holocene there were identified relict Pleistocene species - bison and horse. Also, short data of the size of Holocene animals from Ust-Keul I is presented as well as comparison of different archaeological objects. Other products of fossil mammals remains treatment are also presented.