The article describes basic stages of archaeological studies of Paleolithic multilayer site Afontov mountain II. This represents the conclusion of more than 100 years studies of the site. The main place in the article is occupied by the studies of 1992-2013. The extracted materials of recent years - more than 15,400 items - show the complex interactions between human being and nature of the Afontov mountain II site in the Paleolithic. The tool set is represented mostly by non-characteristic modes, besides, there is a large percentage of so called combined tools. On the other side, when comparing materials of different cultural layers one can clearly see the identity of technical and typological groups of stone inventory. Bone inventory includes tips, needles, awls, ornaments, phallic ivory items, bone preforms, portable art objects testify the unique character of this site. In general, all the osteological material shows the maximal utilization of bones by the ancient man. Based on the work of 2011-2013, we can consider the Afontov mountain's borders to be wider than it was presupposed. Moreover, the structure of this ancient site is more complicated and represents a large set of archeological objects of different times (both short-term and long-term).