The work is dedicated to the publication of odontology and osteometric data of two anthropological series from excavations of Orthodox churchyards in Irkutsk. We studied an anthropological materials from Spasski (XVIII century) and Krestovozdvizhenski (the end of XVIII – the beginning of XIX) necropolises, that were consisting from the remains of 591 individuals. The research results allow to characterize the appearance of the population of Irkutsk XVIII – early XIX century. According to the odontology change in the composition of the population manifested in the elimination of the eastern odontologic traits that may be associated with the continuing influx of population from the European part of Russia. However, the data of the odontology of children and adolescents of the Spasski necropolis testify about the initial cross-breeding, that points to the close connections of the Russian population and indigenous Mongoloid peoples. The received osteometric descriptions are similar to characteristics mid-continent adaptive type of person.